Introduction and Mechanistic Aspects

In 1978, Yonemitsu et al. published the three-component reaction of Meldrum s acid 112 with various aldehydes 328 and 

The original Yonemitsn reaction is fonnd relatively rare in contemporary literatnre, but many modifications by exchange of the CH-acidic or the heterocyclic component have been pnblished. These modifications make the Yonemitsn reaction a broadly applied MCR in organic synthesis, thongh their classification being a modification of the Yonemitsu reaction is not always mentioned in the literatnre. 

The recent literature since 2005 dealing with the original Yonemitsu reaction will separately be discussed from the modified Yonemitsu reactions in this chapter. An interesting variation of the mechanism under alkaline conditions will be presented, and at the end, the tetramolecular version of the Yonemitsu reaction will be discussed. 

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Nucleophilic Attack on Ring Carbon 1.03.3.5.1 Introduction and mechanistic aspects... 

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