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Intramolecular Yamaguchi coupling

Another modification illustrates two features that can be useful in synthesis. When 83 was treated with triphenylphosphine and DEAD (Bn is benzyl), cyclization o urred to give benzoxepin (84) in 87% yield. This shows that Mitsunobu conditions can be used for intramolecular reactions and also that an alcohol can be coupled with another OH unit. This transformation was used by Yamaguchi in a synthesis of radulanins." ... [Pg.112]

Coupling of 200 and 205 by Yamaguchi s esterification followed by an intramolecular Wittig-Horner reaction gave the lactone 206, which was deprotected and oxidized to give tylonolide (185 Tr = H). [Pg.25]

See other pages where Intramolecular Yamaguchi coupling is mentioned: [Pg.438]    [Pg.221]    [Pg.221]    [Pg.208]    [Pg.127]    [Pg.87]    [Pg.125]   
See also in sourсe #XX -- [ Pg.594 ]

See also in sourсe #XX -- [ Pg.648 ]

See also in sourсe #XX -- [ Pg.594 ]



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Intramolecular coupling

Yamaguchi

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