Intramolecular oxidative carboamination

Zeng and Chemler developed a copper-catalyzed preparation of six-membered N,S-heterocycle sultam derivatives using 3 equiv. of Mn02 as the oxidant (Scheme 8.122). The enantiomerically enriched N,S-heterocycle sultams were prepared by an asymmetric intramolecular carboamination of alkenes with moderate to good yield and high enantioselectivity. An intramolecular Cu-catalyzed aryl C(sp )-H functionalization process is included for this reaction [54]. 

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