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Intramolecular carbolithiation reactions anionic cyclization

Although the synthesis of dihydrobenzofuran derivatives seems to be not possible by this anionic cyclization methodology, there are some particular examples in which these heterocycles are prepared by an intramolecular carbolithiation reaction. In this respect Baldwin and coworkers described in 1980 the preparation of 350 by rearrangement of 349 when it was treated with BuLi in THF/TMEDA (Scheme 91)151. The most likely explanation starts with an orf/zo-lithiation giving a dilithium intermediate, which undergoes an intramolecular 5-exo carbolithiation reaction affording a 3-lithiomethyldihydrobenzofuran... [Pg.366]

See other pages where Intramolecular carbolithiation reactions anionic cyclization is mentioned: [Pg.296]    [Pg.297]    [Pg.306]    [Pg.315]    [Pg.329]    [Pg.334]    [Pg.342]    [Pg.342]    [Pg.3]    [Pg.316]    [Pg.322]    [Pg.333]   
See also in sourсe #XX -- [ Pg.105 , Pg.300 , Pg.309 , Pg.339 ]



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Anionic cyclization intramolecular carbolithiation

Anionic intramolecular

Carbolithiation intramolecular

Carbolithiations

Cyclization reactions

Cyclization reactions anionic

Cyclizations intramolecular

Intramolecular cyclization

Intramolecular reactions carbolithiation

Intramolecular reactions cyclizations

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