Intraligand Metal-Assisted Binding

Stepwise protonation of a macrobicyclic ligand 110 and its complexation with copper(II) ion have been thoroughly studied in [68]. This ligand undergoes protonation to give up to hepta-protonated maCTobicyclic species this heptaca-tion has been detected in the presence of 

Protonation and binding properties of a pentamethylene-containing Ugand 111 as 

The hexaimine binucleating caging Ugand 1 forms cascade 1 2 1 cage complex with two copper(ll) ions and one bridging OH anion by 

The potentiometric titration has been used in [75] to study coordination-chemical properties of the furan-based macrobicyclic ligand 10 with copper(II) ions at different pH in the absence and in the presence of halide ions. This ligand forms homoguest 1 2 and heteroguest 1 2 1 copper(II) 

In the C2-symmetric binuclear copper(II)-con-taining heteroguest 1 2 1 cage complex of 7, the encapsulated / 2-azide anion forms a linear Cu. ..N = N - N ...Cu chain, and stacking interactions between it and the aromatic fragments of the encapsulating macrobicyclic ligand at the distance of approximately 3.06 A have been observed in [83]. 

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