Intracellular traffic Protein sorting

The chapter on membrane biochemistry in the previous edition has been split into two, yielding two new chapters on the structure and function of membranes and intracellular traffic and sorting of proteins. 

Section VI consists of discussions of eleven special topics nutrition, digestion, and absorption vitamins and minerals intracellular traffic and sorting of proteins glycoproteins the extracellular matrix muscle and the cy-toskeleton plasma proteins and immunoglobulins hemostasis and thrombosis red and white blood cells the metabolism of xenobiotics and the Human Genome Project. 

Specihc membrane and membrane-associated proteins also control the organelle traffic and fusion events that are associated with the movement of proteins between different intracellular compartments. Membrane proteins of the secretory and endocytic pathways depend on sorting signals that reside in their cytoplasmic domains. Many proteins exhibit multiple signals that determine their passage along these diverse pathways. Therefore, the steady-state distribution of any given membrane... 

Blobel (1980) assumes that parts of a protein sequence bear information for different processes termed as intracellular protein topogenesis. Topogenetic sequences include signal sequences, transfer sequences which interrupt the translocation process, sorting sequences which determine translocational traffic and insertion sequences which initiate integration of proteins into the lipid bilayer of a membrane (see also Marx, 1980). Thus, beside the genetic code which determines sequence, a so-called zip code determines destination of proteins into the cell. Silhavy et al (1977) succeeded in moving to the outer... 

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