Intracellular patch electrochemistry

In the amperometric mode all easily oxidized molecules (including catechols) are detected whereas in the voltammetric mode catecholamines can be preferentially measured. Because membrane capacitance is recorded simultaneously, it is possible to determine if exocytosis is taking place and how it affects cytosohc catecholamine concentration in real time. Figure 17.1.16 shows representative voltammetric data for intracellular patch electrochemistry. 

Figure 17.1.15 Schematic diagram of the intracellular patch electrochemistry setup. Amp 1, Amp 2, Amplifiers GND, electric ground CFE, carbon fiber electrode PP, patch pipette. Reproduced with...

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