Intermolecular Domino Nitro-Michael Additions of C-Nucleophiles

4 Intermolecular Domino Nitro-Michael Additions of C-Nucleophiles 

Domino Michael reactions of aldehydes with ( )-5-iodo-l-nitropent-1-ene. 

Finally, Sankararaman et al. have reported the synthesis of chiral nitro-chromenes on the basis of an asymmetric domino Michael-Henry reaction followed by dehydration, involving nitrostyrene and orlho-hydio-xybenzaldehyde. This reaction was catalysed by a novel C2-symmetric bis-(pyrrolidine-triazole)-based organocatalyst and provided only moderate yields (22-40%) and poor enantioselectivities (7-24% ee). 

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