Intermolecular Domino Michael Additions of -Nucleophiles

The great potential of asymmetric domino processes to generate chemical efficiency through the formation of multiple new bonds and stereocentres in a one-pot system is amply documented. This strategy avoids time-consuming and 

In 2008, Cordova et al. reported the silylated biphenylprolinol-catalysed domino Michael addition-a-alkylation reaction between 2-bromonitromethane and a,(3-unsaturated aldehydes. This highly enantioselective process provided 

Silylated biphenylprolinol-catalysed domino Michael addition-Morita-Baylis-Hillman reactions. 

Another diarylprolinol ether has been used to catalyse several asymmetric domino Michael reactions. Therefore, Jorgensen et al. have demonstrated its efficiency for the asymmetric synthesis of 1,4-dihydropyridines, which are closely related to the NADH system, a biological system of utmost importance, and moreover these molecules are important drugs used in the treatment of a number of diseases, such as cardiovascular diseases and Alzheimer s disease. Thus, a series of chiral 1,4-dihydropyridines were prepared on the basis of a one-pot multicomponent reaction between a a,p-unsaturated aldehyde, a P-diketone 

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