Intermolecular carbomagnesiation

The development of a catalytic system leading to an intermolecular carbomagnesiation of simple aikynes has been a challenge. In 1972, Duboudin and Jousseaume reported the Ni-catalyzed carbomagnesiation of aikynes (Scheme Although this may be one... 

Normant and coworkers demonstrated that the intermolecular carbomagnesiation across acetylene (HC=CH) could be catalyzed by a copper salt . The treatment of w-heptylmag-nesium bromide with acetylene in the presence of a catalytic amount of CuBr (5 mol%) in EtgO at —20 °C followed by the reaction with C2H5CHO and quenching with H2O results in the formation of allylic alcohol 12 in 31% yield (Scheme 9) . The carbomagnesiation takes place in a yw-addition manner. 

The application of copper-catalyzed intermolecular carbomagnesiation of a double bond in the synthesis of alkyhdenecyclopropanes (ACPs) has been reported by our research group [23]. As AGP derivatives have proved their high value in... 

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