Interleukin asthma severity

Much inflammation in asthma is thought to be a consequence of the inappropriate accumulation of eosinophils and the subsequent release of their potent proinflammatory arsenal that includes such diverse elements as granule-derived basic proteins, mediators, cytokines, and chemokines (5). Interleukin (lL)-5 is cmcial to the development and release of eosinophils from the bone marrow, their enhanced adhesion to endothelial cells that line the postcapillary venules, and their persistence, activation, and secretion in the tissues. Several animal models of asthma including the use of primates have provided good evidence... 

Kips JC, O Conner BJ, Langley SJ, Woodcock A, Kerstjens HAM, Postma DS, Danzig M, Cuss F and Pauwels RA. Effect of SCH55700, a humanised anti-human interleukin-5 antibody in severe persistent asthma - a pilot study. Am. J. Resp. Crit. Care. Med. 2003 167 1655-1659. 

Lim S, Crawley E, Woo P, Barnes PJ (1998) Haplotype associated with low interleukin-10 production in patients with severe asthma. Lancet 352 113... 

Kips, J.C., O Connor, B.J., Langley, S.J., Woodcock, A., Kerstjens, H.A. et cd. (2003) EfFectofSCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma a pilot study. American Journal of Respiratory and Critical Care Medicine, 167, 1655-1659. 

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