Interconversion of Acid Derivatives by Nucleophilic Acyl Substitution

Structure and Nomenclature of Acid Derivatives 982 21-3 Physical Properties of Carboxylic Acid Derivatives 988 21-4 Spectroscopy of Carboxylic Acid Derivatives 991 21-5 Interconversion of Acid Derivatives by Nucleophilic Acyl Substitution 997... [Pg.19]

Interconversion of Acid Derivatives by Nucleophilic Acyl Substitution 997... [Pg.997]

This chapter will discuss methods for the preparation of esters, acid chlorides, anhydrides, and amides from carboxylic acids, based on acyl substitution reactions. Acyl substitution reactions of carboxylic acid derivatives will include hydrolysis, interconversion of one acid derivative into another, and reactions with strong nucleophiles such as organometallic reagents. In addition, the chemistry of dicarboxylic acid derivatives will be discussed, as well as cyclic esters, amides, and anhydrides. Sulfonic acid derivatives will be introduced as well as sulfate esters and phosphate esters. Finally, nitriles will be shown to be acid derivatives by virtue of their reactivity. [Pg.944]