Interactomes Human Development

Parks, D S. Lee, D. Bolser, M. Schroeder, M. Lappe D. Oh, and J. Bhak. 2006. Comparative interactomics analysis of protein family interaction networks using PSIMAP(protein structural interactome map). Bioinformatics 21, 3234-3240. Peri, S. et al. 2003. Development of humanprotein reference database as an initial platform for approaching system biology in humans. Genome Res. 13, 2363-2371. 

The use of experimental orthogonal approaches has demonstrated that Y2H and TAP-MS interaction data sets contain mostly highly reliable interactions. It has been suggested that the integration of data from the two approaches can also serve to increase confidence in either data set, and has provided support to derivate predictions from these approaches (Cusick et ah, 2005). Moreover, Venkatesan et ah, (2009) have developed a framework to estimate various quality parameters associated with currently used methods to identify PINs. The combination of these quality parameters (screening completeness, assay sensitivity, sampling sensitivity, and precision), has shown an estimate of the size of human binary interactome and a path toward the completion of its mapping (Venkatesan et ah, 2009). 

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