Interactions Between DNA and Cisplatin

The energy surfaces for formation of the first adducts are given in Fig. 4.10. The barriers to addition are all very high, 35-40 kcal mol-1, a value much too high for any significant amount of adduct formation under physiological conditions. The most probable expla- 

For the second substitution reaction, we have chosen to start from the guanine complex of conformer 1 only. The optimized geometric structures for the reactant complexes, transition states, 

Although the basic geometrical features are the same as in the first substitution, an interesting difference between the two substi- 

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