Integrins hybrid domains

The j3 subunit I-like domain, which is inserted in the hybrid domain of the /3-subunit (Fig. 2A), directly binds ligand in integrins that lack I domains in the a subunit (Fig. 3C, Fig. 6A). By contrast, when the I... 

Mould, A. P., Barton, S. J., Askari, J. A., McEwan, P. A., Buckley, P. A., Craig, S. E., and Humphries, M.J. (2003b). Conformational changes in the integrin j3A domain provide a mechanism for signal transduction via hybrid domain movement. / Biol. Chem. 278, 17028-17035. 

---