Integrins headpiece

Very recently, molecular electron microscopic image of a complex between the integrin headpiece and its physiological ligand, the... 

Luo, B.-H., Springer, T. A., and Takagi, J. (2003b). Stabilizing the open conformation of the integrin headpiece with a glycan wec e increases affinity for ligand. PNAS 100, 2403-2408. 

F. Structure of the Headpiece in Integrins that Lack I Domains. 37... 

Fig. 3. Conformational states for integrins. A-C. Model for a l3 integrin activation, with at least three conformations of the extracellular domain (Takagi et al, 2002). (A) Bent, low affinity conformation. (B) Extended conformation with closed headpiece. (C) Extended conformation with open headpiece shown with bound RGD-mimetic peptide (green CPK). D-H. Model for aiJ3 integrin activation. (D) Bent conformation with low affinity. (E) and (F) with a closed headpiece and closed I domain in...

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