Integrin-mobilferrin pathway

Immobilized metal-affinity chromatography Na+-dependent alanine-insensitive proline uptake system (SLC6A20) Integrin-mobilferrin pathway membrane protein system involved in the transport of ferric iron also inosine-5 - monophosphate Inducible oxide synthetase Iifitiator element Inositol 1,4,5-triphosphate Immobilized pH gradient Isopropylthio-p-D-galactosidase Isopropylthio-p-D-galactopyranoside Inverted repeat insulin receptor... 

Pathway (IMP) uptake of iron. Blood 81, 517-521,1993 Wolf, G. and Wessling-Resnick, M., An integrin-mobilferrin iron transport pathway in intestine and hematopoietic cells, Nutr. Rev. 52, 387-389, 1994 Conrad, M.E. and Umbreit, J.N., Iron absorption and transport — an npdate, Amer. J. Hema-tol 64, 287-298, 2000 Umbreit, J.N., Conrad, M.E., Hainsworth, L.N., and Simovich, M., The ferrireductase paraferritin contains divalent metal transporter as well as mobilferrin. Am. J. Physiol. Gastrointest. Liver Physiol 282, G534-G539, 2002. 

Yet another potential pathway for NTBI uptake by intestinal and erythroid cells has been proposed involving integrins and mobilferrin (Conrad and Umbreit, 1993 Conrad et ah, 1994), although its physiological relevence remains uncertain. 

Cohen A, Martin M, Schwartz E (1984) Depletion of excessive liver iron stores with desferrioxamine. Br J Haematol 58 369-373 Conrad ME (1993) Excess iron and catastrophic illness. Am J Hematol 43 234-236 Conrad ME, Umbreit JN (1993) Iron absorption - the mucin-mobilferrin-integrin pathway. A competitive pathway for metal absorption. Am J Hematol 42 67-73 Conrad ME, Umbreit JN, Peterson RDA, Moore EG, Harper KP (1993) Function of integrin in duodenal mucosal uptake of iron. Blood 81 517-521 Cooper SR, McArdle JV, Raymond KN (1978) Siderophore electrochemistry relation to intracellular iron release mechanism. Proc Natl Acad Sci USA 75 3551-3554... 

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