Naltrexone Insulin

The insulin requirements of a patient rose by about 30% when naltrexone was given. 

The general clinical importance of this interaction is not known but it would be prudent to be alert for any evidence of increased insulin requirements if naltrexone is used in any patient. 

For example hydrophobic drugs such as cisplatin, lidocaine, naltrexone, and progesterone, and hydrophilic drugs such as insulin, proteins, peptide, and vaccine. 

---