Insulin buccal spray

These can be sprayed orally onto the buccal or the sublingual membrane to achieve a local or a systemic effect. One such spray called insulin buccal spray (IBS) was developed with soybean lecithin and propanediol [94], Soybean lecithin has high affinity for biomembranes but does not enhance the transport of drugs due to low solubility. Propanediol can improve the solubility of soybean lecithin, and act as an enhancer. IBS was administered to diabetic... 

Insulin Buccal Spray Oral-lyn Generex Biotechnology Corp. 

Alternative routes for administering insulin are also being considered.51 In particular, a form of insulin (Exubera) has been developed that can be administered by inhalation or nasal spray, thus precluding the need for subcutaneous injection.88,104 Other modifications of the insulin molecule or use of chemical enhancers can increase the permeability of this hormone so that insulin can be administered through the skin (transcu-taneously) or even via oral or buccal routes.2,35 Technologic and practical advancements in insulin delivery continue to be explored, and methods for administering insulin may be safer and more convenient in the future. 

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