Stack inosine

Figure 2 The active site of inosine monophosphate dehydrogenase, drawn from PDB file IJRl. This shows the inhibitor mycophenolic acid at the active site, stacking against PLP. The K+ site is distant from the active site...

Table III contains data on the influence of the ribose moiety upon the stacking association with tryptamine, by comparing bases and the respective nucleosides. In both cases i. e. with adenosine and inosine there is an increase in the affinity which nu be explained by an additional bond moment generated through the attachment of the ribose. However there may be other contributions of the ribose related to the interaction with the solvent.

---