Inorganic base-promoted activation, acidic

Inorganic Base-Promoted Activation of Acidic Organic Compounds... 

Many reactions in organic synthesis are reactions of nucleophiles and electrophiles, in other words they are acid-base reactions. Usually, the nucleophilicity or the electrophilicity of a substrate is enhanced by strong acid or base to promote a reaction. However, a reaction can be also promoted when weak acid and base activate both a nucleophile and an electrophile at the same time. In a homogeneous medium, acid and base could not coexist because of neutralization. Therefore, it is not expected to promote a reaction by acid and base cooperation. However, acid and base supported on an inorganic solid make it possible to promote a reaction by acid and base cooperation. 

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