Inner stratum corneum lipids

Norlen, L. et al., A new HPLC-based method for the quantitative analysis of inner stratum corneum lipids in vivo with special reference to the free fatty acid fraction, Arch. Dermatol. Res., 290, 508, 1998. 

Cevc and Blume, however, suggested that it was possible for whole vesicles to cross intact stratum corneum. The basic premise for this hypothesis was the driving force provided by the osmotic gradient between the outer and inner layers of the stratum corneum and the development of specific mixes of lipids to form modified liposomes termed transfersomes. The requirement for the osmotic gradient to be maintained suggests that transfersomes will not function in occlusive conditions and careful formulation is necessary. Due to their unique structure (a mix of phosphatidyl choline, sodium cholate, and ethanol), transfersomes... 

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