Initiation, Elongation, and Termination in Eukaryotes

Activation tRNAs, ATP, Mg2+ aminoacyl-tRNA synthetases tRNAs, ATP, Mg2+ aminoacyl-tRNA synthetases [Pg.335]

Initiation mRNAs with AUG initiation code fMet-tRNAi IF-1, IF-2, and IF-3 initiation factors, GTP, Mg2+ 30 and 50 S mRNAs with AUG initiation code Met-tRNA eIF3, eIF2, eIF4, eIF5 initiation factors GTP, Mg2+, eIF-2 protein kinase 40 and 60 S ribosomal subunits [Pg.335]

Elongation Functional 70 S ribosomes aminoacyl-tRNAs GTP, Mg2+, EF-Tu, EF-Ts, and EF-G elongation factors Functional 80 S ribosomes aminoacyl-tRNAs GTP, Mg2+, EF-1, EF-1, and EF-2 elongation factors [Pg.335]

Termination Termination codons (UAG, UAA, or UGA) recognized by RF-1, RF-2, and RF-3 release factors Termination codons (UAG, UAA, or UGA) recognized by eRF release factor [Pg.335]

Chloramphenicol Binds to 50 S ribosomyl subunit and inhibits peptidyltransferase [Pg.336]

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