Inhibitors and modulators

Secretase Inhibitors and Modulators for the Treatment of Alzheimer s Disease... 

Alkylpyridinium compounds as enzyme inhibitors and modulators of various receptors... 

Imbimbo BP. Therapeutic potential of gamma-secretase inhibitors and modulators. Curr Top Med Chem. 2008 8(1) 54-61. 

Secretase inhibitors (0- and y-secretase inhibitors and modulators) 2 - Amino -1,3 - oxazine Avagacestat AZ-4217... 

Golde TE, Koo EH, Felsenstein KM, Osborne BA, Miele L (2013) y-Secretase inhibitors and modulators. Biochim Biophys Acta 1828(12) 2898-2907... 

Sur C, Kinney GG (2007) Glycine transporter 1 inhibitors and modulation of NMDA receptor-mediated excitatory neurotransmission. Curr Drug Targets 8 643-649... 

The area that appears to be very promising and noticeable in terms of research of substances affecting AD is represented by mitochondrial dysfunction inhibitors and modulators of cellular energy production. It is a complicated problem, hard to grasp, but it is a major challenge in the field of research of small molecules intervening in the development of AD, as the recent literature clearly defined. 

Figure 1. The porphyrin synthesis pathway and sites of inhibition of various inhibitors and modulators. Inhibitors are underlined and sites of inhibition are indicated...

Legraverend, M. and Grierson, D.S. (2006) The purines potent and versatile small molecule inhibitors and modulators of key biological targets. Bioorg. Med. Chem., 14, 3987-4006. 

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