Lorazepam Influenza vaccines

The pharmacokinetics of alprazolam, chlordiazepoxide and lorazepam are not affected by influenza vaccination. 

The pharmacokinetics of single doses of oral alprazolam 1 mg, or intravenous lorazepam 2 mg remained unaffected in healthy subjects when the benzodiazepines were given 7 and 21 days after 0.5 mL of an intramuscular trivalent influenza vaccine. Similarly, in another study, neither lorazepam nor chlordiazepoxide metabolism was altered when they were given 1 and 7 days after a trivalent influenza vaccine. There would seem to be no reason for avoiding the concurrent use of these drugs. 

Scavone JM, Blyden GT, Greenblatt DJ. Lack of effect of influenza vaccine on the pharmacokinetics of antip3nine, alprazolam, paracetamol (acetaminophen) and lorazepam. ClinPharma-... 

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See also in sourсe #XX -- [ ]

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