Influence of Mesh Size

Diffusion of Macromolecules in Mucus 2.7.1 Influence of Mesh Size... 

When considering the influence of mesh size it is important to recognize the effect of other mucus components (see below) and also that the GI mucus appears to comprise two continuous but distinct layers the outer, loosely adherent mucous layer and the inner, firmly adherent mucus layer (Atuma et al. 2001). These mucus layers differ in thickness (Table 2.2) and perhaps organization (pore mesh), although the underlying reason for this intramucus compartmentalization has not yet been determined. The fact that the inner mucus layer is most abundant and the ratio of inner layer/ outer layer thickness is larger in the stomach supports the view that the former has a protective function while the latter would mainly function as a lubricant (Atuma et al. 2001). 

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