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Inflammatory chemokine-mediated neuronal

Besides the well-established role of cytokines in the immune system, several recent reports demonstrated that chemokines also play a role in the central nervous system (CNS) (B2, Ml3). In the CNS, chemokines are constitutively expressed by microglial cells, astrocytes, and neurons, and their expression can be increased after induction with inflammatory mediators (M13). Chemokines are involved in brain development and in the maintenance of normal brain homeostasis, and play a role in the migration, differentiation, and proliferation of glial and neuronal... [Pg.19]

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