Inflammation/inflammatory agents

Polansky, J. and Weinreb, B. (1984). Anti-inflammatory agents steroids as anti-inflammatory agpnts. In Pharmacology of the Eye (ed. M.L. Sears) pp. 459-538. Springer Verl, Berlin. Rao, N., Romero, J., Fernandez, M. and Marak, G.E. (1986). Effect of iron chelation on severity of occular inflammation in an animal model. Arch. Ophthalmol. 104, 1369-1371. 

Ebselen is a seleno-oiganic that mimics glutathione peroxidase and inhibits iron-stimulated lipid peroxidation. It significandy reduced both inferct size and oedema progression in the middle cerebral artery exclusion (MCAO) focal model of stroke in tats (Matsui et al. 1990). Ebselen has also been shown to be an effective anti-inflammatory agent in a H202-dependent inflammation model in tats (Parnham 1991). 

Corticosteroids are the most potent anti-inflammatory agents available for the treatment of asthma. The efficacy of corticosteroids is due to their ability to affect multiple inflammatory pathways, resulting in the suppression of inflammatory cell activation and function, prevention of microvascular leakage, decreased mucus production, and upregulation of P2-adrenergic receptors.10,18 Clinically, corticosteroids decrease airway inflammation, decrease AHR, decrease mucus production and secretion, and improve the response to P2-agonists.18 Corticosteroids for the treatment of asthma are available in inhaled, oral, and injectable dosage forms. 

Anti-inflammatory agents may be used in conjunction with artificial tears. The only approved agent is cyclosporine emulsion. Administered topically, it is thought to act as a partial immuno-modulator suppressing ocular inflammation, but the exact mechanism is unknown. Cyclosporine emulsion increases tear production in some patients. Fifteen minutes should elapse after instillation of cyclosporine before artificial tears are instilled.31 Use of topical corticosteroids for short periods (e.g., 2 weeks) may suppress inflammation and ocular irritation symptoms. No topical corticosteroid is approved for this indication, however.30... 

Anti-Inflammatory Agents Substances that reduce or suppress inflammation, [nih]... 

Aspirin A drug that reduces pain, fever, inflammation, and hlood clotting. Aspirin belongs to the family of drugs called nonsteroidal anti-inflammatory agents. It is also being studied in cancer prevention, [nih]... 

Glucocorticoids are effective and potent anti-inflammatory agents. Regardless of the cause of the inflammation, glucocorticoids attenuate the heat, erythema, swelling, and tenderness of the affected area. The exact way that these agents intervene in the inflammatory process is complex and not completely under-... 

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