Infiltration of leukocytes to the inflammatory

The other meehanism of extravasation mimies the infiltration of leukocytes to the inflammatory site, a process which requires adhesion of mmor and endothelial cells. When leukocytes are attracted to the site of inflammation via chemokine gradient, their extravasation occurs in four steps (Rao et al. 2007). In the first step, leukocytes adhere to the vessel wall via selectin moleeules and roll along the endothelium surface (a reversible process). The second step is tight adhesion of leukoeytes to the endothelium through other adhesion moleeules on the endothelial eeUs sueh as... 

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