Industrial fine chemicals, palladium-catalyzed

Beller, M., Zapf, A. Palladium-catalyzed coupling reactions for industrial fine chemical syntheses. Handbook of Organopalladlum Chemistry for Organic Synthesis 2002, 1, 1209-1222. 

IV.2.1.3 Palladium-Catalyzed Coupling Reactions for Industrial Fine Chemicals Syntheses... 

Transition metal complexes, zeolites, biomimetic catelysts have been widely used for various oxidation reactions of industrial and environmental importance [1-3]. However, few heterogenized polymeric catalysts have also been applied for such purpose. Mild condition oxidation catalyzed by polymer anchored complexes is attractive because of reusability and selectivity of such catalysts. Earlier we have reported synthesis of cobalt and ruthenium-glycine complex catalysts and their application in olefin hydrogenation [4-5]. In present study, we report synthesis of the palladium-glycine complex on the surface of the styrene-divinylbenzene copolymer by sequential attachment of glycine and metal ions and investigation of oxidation of toluene to benzaldehyde which has been widely used as fine chemicals as well as an intermidiate in dyes and drugs. 

The antiviral bromoindole alkaloid dragmacidin F and the potent natural antitumor agent (-f-)-dynemicin A involve a Suzuki coupling in one of the key carbon-carbon bond-forming steps (Figure 10.1) [8, 9). Further examples of industrially prepared fine chemicals involving palladium-catalyzed cross-coupling... 

Figure 10.1 Palladium-catalyzed cross-coupling reactions in natural product synthesis and industrially prepared fine chemicals.

Torborg C, Seller M (2009) Recent appUcations of palladium-catalyzed coupling reactions in the pharmaceutical, agrochemical, and fine chemical industries. Adv Synth Catal 351 (18) 3027-3043... 

The literature on the potential applications of Pd-catalyzed crosscoupling reactions for the syntheses of specialty chemicals, pharmaceuticals, and fine chemicals is vast. We begin with two of the earliest examples of industrial applications of Heck-Mizoroki reactions. As shown by (7.4.2.1) and (7.4.2.2), for making the herbicide Prosulfuron and the analgesic R-naproxen, palladium-catalyzed crosscoupling reactions are used in the first steps. 

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