Indirect LMW Modulators of the NR4A Subfamily

Studies have shown that NR4A1, NR4A2 and NR4A3 are rapidly modulated in different cell types by a variety of small molecules. 

Finally, forskolin induced upregulation of NR4A2 protein expression and nuclear translocation in MN9D cells was shown to be mediated primarily through the ERK1/2 pathway [96]. 

While a growing number of such modulators of activity or expression have been described, none seems selective enough to help in the elucidation of NR4A s mechanism of action or as potential therapy. 

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