INDEX pilocarpine

Various lecithin-based MEs were also characterized by Hasse and Keipert [131]. The formulations were tested in terms of their physicochemical parameters (pH, refractive index, osmolality, viscosity, and surface tension) and physiological compatibility (HET-CAM and Draize test). In addition, in vitro and in vivo evaluations were performed. The tested MEs showed favorable physicochemical parameters and no ocular irritation as well as a prolonged pilocarpine release in vitro and in vivo. 

Zimmerman TJ, et al. Therapeutic index of pilocarpine, carba-chol, and timolol with nasolacrimal occlusion. Am J Ophthalmol 1992 114 1-7. 

Detection of pilocarpine is most sensitive at its UV maximum of 215 nm. However, detection at 220 nm improves the stability of the baseline, whereas only a minor decrease - 5511 - of the peak height of pilocarpine is observed as compared with 215 nm10. The detection limit at 215 nm is about 0.04 ug, the detection limit obtained for the refractive index method is about 6 ug9. 

The microemulsions containing pilocarpine were formulated using lecithin, propylene glycol, and PEG 200 as co-surfactant and isopropyl myristate as the oil phase. The formulations were of low viscosity with a refractive index lending to ophthalmologic applications. ... 

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