INDEX pain control

While it is often held that genetic polymorphisms are most important when they affect drugs that have a narrow therapeutic index for which dangerous toxicity may result or perilous lack of effect may ensue/ this need not be the case. For example/ CYP2D6 converts codeine/ likely the most widely prescribed opiate in the world and the mainstay of pain control for a large number of patientS/ to its active metabolite morphine. ThuS/ patients who have deficient CYP2D6 are unable to make morphine/ and pharmacodynamic studies have shown that this results in decreased pain... 

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