Indandione derivatives

Anticoagulants used therapeutically include heparin, warfarin (a coumarin derivative), and anisindione (an indandione derivative). 

Coumarin and indandione derivatives are affected by many drugs. Those that may... 

Vitamin K can antagonize coumarinic acid compounds (warfarin and its congeners) and indandione derivatives. Vitamin K exists in several forms including simple water-soluble menadione [58-27-5] (9)... 

In the region of spectral studies, Perjessy has made extensive studies on indandione derivatives (57), demonstrating that the carbonyl... 

The likely reason for the unusually high reactivity of the Meldrum s acid and 1,3-indandione derivatives is that the transition state is subject to extra stabilization by intramolecular hydrogen bonding solvation as shown in X for... 

Bromomalonate, selected as the pronucleophile, is proposed to undergo deprotonation by the diaryl prolinol catalysts lej to give the corresponding reactive enolate involved in the conjugate addition with different electron-poor alkenes (Scheme 7.9). The intramolecular alleviation proceeds with more nucleophilic indandione-derived enolate, under one-pot conditions, in... 

Structure-activity relationship has been investigated in 1,3-indandione derivatives using the rabbit as the experimental animal. Derivatives with ethyl and tert-butyl radicals in the side chain had the highest activity 2-Phenylbenzo [bj thiophen-3-(2H)-one 1,1 dioxide was shown to exhibit both anticoagulant and anti-inflammatory activity. Various analogs were prepared and separation of the anti-infl unmatory activity from the anticoagulant affect was achieved ... 

Anticoagulant therapy in recent years has involved the use of either heparin or the oral anticoagulants, coumarln and indandione derivatives, on venous thrombosis. The only newer agents with clinical potential appear to be several snake venoms or venom fractions which act either through defibrlnogenatlon or inhibition of prothrombin activation. 

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