In vitro false positives

Rishton, G. M. Reactive compounds and in vitro false positives in HTS. Drug Discov. Today 1997, 2, 382-384. 

Rishton, G.M. Reactive Compounds and In Vitro False Positives in HTS. Drug Discovery Today, 1997,2,382-384. 

FIGURE 12.4 Reactive functional groups responsible for in vitro false positives (Z = F, Cl, Br, 1, tosyl, mesyl, etc. R = alkyl, aryl, heteroalkyl, heteroaryl, etc.). These reactive functional groups are generally prone to decomposition under hydrolytic conditions (i.e. aqueous Na2C03/methanol). They are reactive toward protein and biological nucleophiles (e.g. glutathione, dithiothreitol), and they exhibit poor stability in serum. ... 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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