Importance of Telomere Ends and Replication Processes

One of the most interesting demonstration that telomere is a significant target for these ligands has been provided by a study using a radiolabelled G-quadruplex ligand. The localization of the chromosomal binding sites of a 

It would be interesting to determine whether such action will be a benefit for antitumor activity. A possible way to determine this is to examine the effect of the ligands in cells defective for these resolvases. A replication block at telomere would be expected to rapidly induce larger deletions of telomeric sequence than in wild-type cells. These results may orient the strategy to select future G-quadruplex ligand or to combine the actual ligands with specific inhibitors of these resolvases. 

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