Importance of Gas Dispersion

In the case of a culture in which oxygen is provided by aeration, it is necessary to operate the reactor above the speed at which the gas is completely dispersed. This allows utilization of the entire vessel volume for gas-liquid contacting. Gas 

STIRRED TANK REACTORS FOR CELL CULTURE TECHNOLOGY 

FIGURE 7B.18 Concentration profile for transfer of oxygen across (A) gas-liqnid film and (C) cell-liquid film. Concentration profiles for transfer of CO across (B) liquid-gas film and (D) cell-liquid film. (Adapted from Nienow (2003) with permission from John Wiley Sons, Inc. 1969.) 

At A=the values of geo QAii spatially uniform. Thus, operating at A=A, (Pi )eo or dissolved CO concentration is also expected to be spatially uniform. 

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