Anderson cascade impactor

Figure 3 Individual stage plates and inlet from the Anderson Cascade Impactor showing the pattern of radioactivity on the plates following sizing of a radiolabeled pMDI formulation. The plates and inlet were placed on the planar gamma camera face and imaged to measure the amount of deposited radioactivity. The plates were subsequently washed with solvent and assayed using UV spectroscopy to obtain the amount of drug deposited.

Fig. 6.26. Anderson cascade impactor a — suctional view, b — characteristics of the separation of aerosol particles at different stages (1-6). A — air flow, B — health hazard region, C — safe area, penetration to lung is not likely...

A cascade impactor operating at 15 L/min would provide an ideal instrument to employ in this standard. Unfortunately, no such device is available. Furthermore, even it were, an impactor operating at 15 L/min would not be able to cope with extension smdies requiring lower airflow rates in, for example, pediatric applications. There are a limited number of devices which operate at lower flows of 1, 2, or 3 L/min of these, the Graseby Anderson 290 series impactor was selected and, in collaboration with the manufacturer, was modified to accommodate nebulized aerosol. This low-flow impactor has additional physical features that help to produce a meaningful estimate of nebulized droplet size, including... 

A. A. Anderson, A Sample for Respiratory Health Hazard Assessment. Am. Ind. Hyg. Assoc. /, 27 (1966), 160-165. Commercial information on the Anderson sampler is available from 2000, Inc., 5899 South State Street Salt Lake City, Utah, USA 84107. K. R. May,/, Sci. Instrum, 22 (1945), 187. Commercial information on the May cascade impactor is available from Casella Corporation see reference 21, or BGI Incorporated see reference 42. 

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