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Immunotoxin cystamine

Figure 21.10 Cystamine may be used to make immunotoxin conjugates by a disulfide interchange reaction. Modification of antibody molecules using an EDC-mediated reaction creates a sulfhydryl-reactive derivative. A-chain toxin subunits containing a free thiol can be coupled to the cystamine-modified antibody to form disulfide crosslinks. Figure 21.10 Cystamine may be used to make immunotoxin conjugates by a disulfide interchange reaction. Modification of antibody molecules using an EDC-mediated reaction creates a sulfhydryl-reactive derivative. A-chain toxin subunits containing a free thiol can be coupled to the cystamine-modified antibody to form disulfide crosslinks.
Other reagent systems can be used to form disulfide linkages between antibody and toxin molecules in immunotoxin conjugates. Cystamine can be incorporated into... [Pg.534]

See other pages where Immunotoxin cystamine is mentioned: [Pg.832]    [Pg.844]    [Pg.521]    [Pg.522]    [Pg.501]    [Pg.502]   
See also in sourсe #XX -- [ Pg.844 ]



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