Immunological self-tolerance

Autoimmune diseases in which immunological self-tolerance breaks down and the immune system launches an attack on self-antigens. 

Sakaguchi, S. et al., Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases, J. Immunol. 155, 1151-1164, 1995. 

Itoh M, Takahashi T, Sakaguchi N, Kuniyasu Y, Shimizu J, Otsuka F, Sakaguchi S Thymus and autoimmunity production ofCD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 1999 162 5317-5326. 

SakaguchiS, Sakaguchi N Regulatory T cells in immunologic self-tolerance and autoimmune disease. Int Rev Immunol 2005 24 211-226. 

Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002 3 135-142. 

Sakaguchi S. 2004. Naturally arising CD4+ regulatory T cells for immunologic self tolerance and negative control of immune response. Ann Rev Immunol. 22 531-562. 

N, Shimizu J (2001) Immunologic self tolerance maintained by T-cell-mediated control of self-reactive T cells Implications for autoimmunity and tumor immunity. Microbes Infect 3 911-918. 

Klebb, G. et al. (1996) Interleukin-2 is indispensable for development of immunological self-tolerance. Clinical... 

Takahashi T, Kuniyasu Y, Toda M, Sakaguchi N, Itoh M, Iwata M et al. Immunologic self-tolerance maintained by CD25-I-CD4-I- naturally anergic and suppressive T cells induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 1998 10 1969-1980. 

Sakaguchi, S., Sakaguchi. N..Asano.M., Itoh.M.. and Toda. M. (1995) Immunologic Self-Tolerance Maintained by Activated T Cells Expressing IL-2 Receptor Alpha-Chains (CD25). Breakdown of a Single Mechanism of Self-Tolerance Causes Various Autoimmune Diseases,/. Immunol. 155,1151 1164. 

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