Immobilised antibody column

These adsorbants are based on immobilised ligands, which have a high affinity for a particular analyte (Fig. 15.13). There are examples where antibodies have been raised to an analyte and then bound to the surface of a SPE matrix. Various types of chemistry permit this type of immobilisation and affinity chromatography is well established in biochemistry. With the proliferation with biotechnological products such as therapeutic peptides, the use of these types of columns for extraction may increase since they can be designed to be highly selective for such compounds. 

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