Terbinafine Imipramine

A 51-year-old patient developed imipramine toxicity and increased plasma concentrations associated with the introduction of terbinafine, possibly due to inhibition of CYP2D6 (212). 

TERBINAFINE ANTIDEPRESSANTS- IMIPRAMINE, NORTRIPTYLINE Possible T plasma concentrations ofTCAs Terbinafine strongly inhibits CYP2D6-mediated metabolism of nortriptyline Warn patients to report t side-effects of TCAs such as dry mouth, blurred vision and constipation, which may be an early sign of t TCA levels. In this case, consider i dose of TCA... 

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