Imipenem antimicrobial activity

IV IV infusion over 20 minutes results in peak plasma levels of imipenem antimicrobial activity that range from 14 to 83 mcg/mL, depending on the dose. Plasma levels declined to 1 mcg/mL or less in 4 to 6 hours. Peak plasma levels of cilastatin following a 20-minute IV infusion range from 15 to 88 mcg/mL, depending on the dose. The plasma half-life of each component is approximately 1 hour. Protein binding is 20% for imipenem and 40% for cilastatin. 

Currently, bicyclic (3-lactams such as, imipenem (XIII), panipenem (XIV), and meropenem (XV) have been shown to exhibit broad antimicrobial spectrum and potent bactericidal activity [64—66]. 

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