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Iminodicarboxylic acid Gabriel synthesis

Methyl r-butyl iminodicarboxylate (91) and di-r-butyl iminodicarboxylate (93) have been used in a modified Gabriel synthesis. Thus, the potassium salt of (91) reacted with alkyl halides to give the corresponding A/-alkylated products (92) in 59-95% yields (in DMF or DMSO, 20-60 C) except for alkylating reagents susceptible to base-catalyzed side reactions. Under basic conditions, (92) gave N-t-butoxycarbonylamines, whereas, with trifluoroacetic acid, iV-methoxycarbonylamines were obtained (Scheme 40). ... [Pg.81]

See other pages where Iminodicarboxylic acid Gabriel synthesis is mentioned: [Pg.81]   
See also in sourсe #XX -- [ Pg.6 , Pg.81 ]

See also in sourсe #XX -- [ Pg.81 ]

See also in sourсe #XX -- [ Pg.6 , Pg.81 ]

See also in sourсe #XX -- [ Pg.81 ]



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Gabriel

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