Iminodibenzyl derivatives

Imipramine is the prototype TCA and was the first clinically potent antidepressant dmg. Imipramine and its deriratives are iminodibenzyl derivatives (Kg. 18.16). Both desipramine and lofepramine appear to be more selective towards noradrenaline reuptake (NA) whereas the remaining derivatives are considered to be more non-selective towards SERF and NAT (5-HT/NA), respectively. 

Aminopyridyl derivatives of carbazole, phenoxazine, iminodibenzyl, and phenothiazine have been reported. Thus3-(10-phenothiazinyl)propionic acid gives the corresponding 2-, 3-, and 4-pyridylpropionatnides when boiled with 2-, 3-, or 4-aminopyridine in triethylamine. These pyridylamides are reduced with lithium aluminum hydride to yield the corresponding 2-, 3-, or4-[3-(10-pheno-thiazinyl)propylamino] pyridines. 

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