Iminocyclitol, Pipecolic Acid, Homoiminocyclitols, and Aminocyclitol Synthesis

2 Iminocyclitol, Pipecolic Acids, Homoiminocyclitols, and Aminocyclitol Synthesis 

Two-step chemo-enzymatic synthesis of iminocyclitols (a) aldolase-catalyzed aldol addition and phosphate hydrolysis and (b) one-pot Cbz removal and reductive amination. 

Preparation of diverse pyrrolidine type iminocyclitols mediated by DHAP-dependent aldolases, i-rhamnu-lose-1-phosphate aldolase (RhuA) and i-fuculose-l-phosphate aldolase (FucA) from Escherichia coii. (a) DHAP-dependent aldolase, namely and acid phosphatase to remove the phosphate group, and (b) one-pot Cbz removal and reductive amination. 

N-Cbz-3-aminopropanal and N-Cbz-2-aminoethanal [132], being the linear or branched C-a substituted aminoaldehydes including the prolinal derivatives no substrates. The reductive amination was normally conducted with in the presence of Pd/C. This reac- 

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