Imidazolylboronic acids

Imidazolylboronic acids are not well known. 5-Imidazolylboronic acid was prepared in situ by Ohta s group using selective lithiation at C(5) from 1,2-protected imidazole. However, the subsequent Suzuki coupling with 3-bromoindole gave the expected indolylimidazole in only 7% yield [18]. This observation indicated that more investigation into imidazolylboronic acids is necessary to better understand their synthesis and behavior. 

In contrast to the scarcity of precedents in the imidazolylboronic acids, abundant reports exist on imidazolylstannanes. In the Stille reaction, the imidazole nucleus may serve as either the nucleophile as an imidazole halide or the electrophile as an imidazolylstannane. One advantage of the Stille reaction is that it often tolerates delicate functionalities in both partners. 

Imidazolylboronic acids are not well-known. 5-Imidazolylboronic acid was prepared... 

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