Imidazolines inductive effect

Grubbs examined the effect that a C2 symmetric imidazolin-iiim hgand would have on dichloro-, dibromo-, and diiodo-rutheninm alkylidene catalysts (112a- (Scheme 18). The new complexes had activities and stabihties similar to the parent complex (4a) and were thus tested for asymmetric induction in enantioselective desymmetrization reactions. The /trei using these new complexes were low, leading to very low... 

Such a correlation has never been shown when affinities for a 2-adrenoceptors were taken into account. There is a large body of evidence for the involvement of non-adrenoceptors in the induction of the hypotensive effect of imidazoline-related dmgs (Bousquet, 1995, 1997 Erns-berger et al., 1997 Molderings, 1997). Nevertheless, one should keep in mind that the main side effects of clonidine-like drugs are clearly due to their capability of acti-... 

The isolation of imidazolin-2-ylidenes of type 97 clearly showed that an aromatic 6n-electron system within the heterocycle is not required for the stabilization of an N-heterocyclic diaminocarbene. The singlet carbene center is sufficiendy stabilized by inductive and mesomeric effects caused by the nitrogen substituents leading to N1-C2-N3 n-delocalization. The smaller energy gap between the singlet and triplet states in carbenes of type how-... 

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