Imidazol annulated pyridin

Keywords aldehyde, isocyanide, 2-aminopyridine, montmorillonite K-10, micro-wave irradiation, imidazol[l,2-a]annulated pyridine... 

Substituted imidazo[4,5-c]pyridin-2-ones such as compound (149) upon reaction with iodo-methane gave intractable mixtures rather than the desired product (150). To prepare compound (150) one must first /V-alkylate the imidazole (151) and subsequently annulate <93JMC1341>. 

Rearrangement of alkoxycarbonyl imidazole acryl azides in diphenyl ether at high temperatures afforded imidazo[l,5-c]pyrimidinone or imidazo[4,5-c]pyridinone derivatives <02TL5879>. Efficient synthesis of imidazopyridodiazepines from peri annulation in imidazo[l,2-a]pyridine has been described <02TL9119>. A convenient synthesis of 3,6-disubstituted-2-aminoimidazo[l, 2-a]pyridines has been published <02TL9051>. Novel 2,3-dihydroimidazo[2,l-h][l,3]oxazoles were prepared from intramolecular nucleophilic i/wo-substitution of 2-alkylsulfonylimidazoles <02S2691>. 4,4 -Bi-l//-imidazol-2-ones were efficiently synthesized from 5-amino-ot-imino-1 //-imidazole-4-acetonitriles and isocyanates <02JOC5546>. 

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