Imatinib binding modes

Type I and type II kinase inhibitor binding modes are exemplified in Figure 3.3, which shows PD166326 (6, a) and imatinib (7, b) bound to ABL, represented by ribbon structures (PDB lOPK,11 and IIEP,12 respectively). In the latter, the DFG-out conformation of the activation loop reveals the allosteric site occupied by the benzylpiperazine moiety of imatinib, 7. 

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